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RIBOMIC, Inc. is a leading company in the world developing innovative aptamer therapeutics.

The Action Mechanism of an Aptamer

Currently, nucleic acid drugs in research and development are those shown in the table below. Their action mechanisms are shown in the figure below. However, unlike other nucleic drugs that have to go into the inside of cells, aptamers function outside of cells.

The Action Mechanism of an Aptamer
Category Basic structure Target Mechanism
Aptamer Single stranded RNA/DNA protein Inhibits the physiological effect
Antisense Single stranded DNA mRNA Binds to mRNA and inhibits translation
Decoy nucleic acid Double stranded DNA Transcription factor Traps transcription factor and inhibits transcription
Ribozyme Single stranded RNA mRNA Works as an enzyme to cut the mRNA and controls expression
siRNA Double stranded RNA mRNA Cuts the mRNA and controls expression
miRNA Single stranded RNA mRNA Binds to mRNA and inhibits translation
antimiRNA Single stranded RNA/DNA miRNA Binds to miRNA and inhibits its activity